Brunswick Mechanics' Institute is of local historical and architectural significance. It is one of the earliest surviving, and reasonably intact, Mechanics' Institutes built in Victoria in the 19th century. Brunswick Mechanics' Institute is distinguished by its compact plan and building form, with its unusual juxtaposition of front room with a transverse main hall. It is also unusual for its simple yet classically inspired architectural treatment and roof form. The Institute is an integral element of this part of Sydney Road, which includes many civic and church buildings. The building also derives significance from its role as the a community focus for Brunswick.